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Histamine in Body Fluids: Its Measurement In Different Clinical States

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Measurement of histamine levels in plasma and body fluids is a useful indicator of mast cell or basophil degranulation during pathological reactions. Changes in histamine levels are usually well correlated with changes in pathophysiological parameters. Examples of such correlations in diseases associated with abnormal numbers of mast cells (mastocytosis) and basophils (chronic myelogenous leukemia, polycythemia vera) or reactions associated with mast cell degranulation (asthmatic attacks, physically-induced urticarias, anaphylactic or drug reactions) are described. Procedures developed in the authors' as well as other laboratories and the precautions that should be observed in the measurement of histamine in body fluids are critically reviewed.
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Document Type: Research Article

Affiliations: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, Md. 20205

Publication date: 1984-09-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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