Histamine in Body Fluids: Its Measurement In Different Clinical States
Abstract:Measurement of histamine levels in plasma and body fluids is a useful indicator of mast cell or basophil degranulation during pathological reactions. Changes in histamine levels are usually well correlated with changes in pathophysiological parameters. Examples of such correlations in diseases associated with abnormal numbers of mast cells (mastocytosis) and basophils (chronic myelogenous leukemia, polycythemia vera) or reactions associated with mast cell degranulation (asthmatic attacks, physically-induced urticarias, anaphylactic or drug reactions) are described. Procedures developed in the authors' as well as other laboratories and the precautions that should be observed in the measurement of histamine in body fluids are critically reviewed.
Document Type: Research Article
Affiliations: Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, Md. 20205
Publication date: 1984-09-01
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