Factors Affecting Respiratory Mucus Secretion
Over the last decade much progress has been made toward understanding the factors which affect mucus glycoprotein (MGP) secretion in airways. Research has involved in vivo and in vitro projects in experimental animals as well as in vitro systems using human tissue. Among the neurohormones, cholinergic, alpha adrenergic, and beta adrenergic agonists appear to stimulate secretion while vasoactive intestinal peptide (VIP) reduces MGP secretion. A variety or mediator, released in immediate hypersensitivity reactions in the lung including histamine and arachidonic acid (AA) metabolites such as PG A2, PG D2, PG F2α, hydroxyeiocosatetraenoic acids, and the leukotrienes C4 and D4 among others appear to stimulate MGP secretion. Less information is available on substances which might reduce MGP secretion; however, colchicine, VIP, and corticoseroids are described.
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Document Type: Research Article
Affiliations: Department of Critical Care Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland
Publication date: 1984-06-01
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