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Factors Affecting Respiratory Mucus Secretion

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Over the last decade much progress has been made toward understanding the factors which affect mucus glycoprotein (MGP) secretion in airways. Research has involved in vivo and in vitro projects in experimental animals as well as in vitro systems using human tissue. Among the neurohormones, cholinergic, alpha adrenergic, and beta adrenergic agonists appear to stimulate secretion while vasoactive intestinal peptide (VIP) reduces MGP secretion. A variety or mediator, released in immediate hypersensitivity reactions in the lung including histamine and arachidonic acid (AA) metabolites such as PG A2, PG D2, PG F2α, hydroxyeiocosatetraenoic acids, and the leukotrienes C4 and D4 among others appear to stimulate MGP secretion. Less information is available on substances which might reduce MGP secretion; however, colchicine, VIP, and corticoseroids are described.
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Document Type: Research Article

Affiliations: Department of Critical Care Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland

Publication date: 1984-06-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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