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Role of Airway Epithelial Ion Transport in Pulmonary Mucociliary Clearance

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Mucociliary clearance is an important pulmonary defense mechanism that serves to remove inhaled particulate material from the lung. Effective function of the mucociliary clearance apparatus is dependent upon ciliary activity, the viscoelastic mucus, and ion transport by the airway epithelia. Recent studies of the airway epithelium show that it is capable of either active Na absorption or Cl secretion and that the direction and magnitude of salt and water transport is under neurohumoral control. Finally, there is increasing evidence that abnormalities of epithelial ion transport may be important in the pathogenesis of a variety of pulmonary diseases. Further investigation of both the normal and abnormal physiology of epithelial ion transport should increase our understanding of the mechanisms involved and may lead to the development of more rational therapeutic modalities.

Document Type: Research Article


Affiliations: Pulmonary Disease Division and Laboratory of Epithelial Transport, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242

Publication date: June 1, 1984

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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