Role of Airway Epithelial Ion Transport in Pulmonary Mucociliary Clearance
Abstract:Mucociliary clearance is an important pulmonary defense mechanism that serves to remove inhaled particulate material from the lung. Effective function of the mucociliary clearance apparatus is dependent upon ciliary activity, the viscoelastic mucus, and ion transport by the airway epithelia. Recent studies of the airway epithelium show that it is capable of either active Na absorption or Cl secretion and that the direction and magnitude of salt and water transport is under neurohumoral control. Finally, there is increasing evidence that abnormalities of epithelial ion transport may be important in the pathogenesis of a variety of pulmonary diseases. Further investigation of both the normal and abnormal physiology of epithelial ion transport should increase our understanding of the mechanisms involved and may lead to the development of more rational therapeutic modalities.
Document Type: Research Article
Affiliations: Pulmonary Disease Division and Laboratory of Epithelial Transport, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242
Publication date: June 1, 1984
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