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Clinical Impact and Future of Monoclonal Antibodies

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Abstract:

In 1975, Köhler and Milstein immortalized single cells producing monoclonal antibody of defined specificity by fusing them with myeloma cells in continuous culture. Since then, the use of monoclonal antibodies has increased exponentially and provided new insights into the cellular interactions involved in immunoregulation. This review will consider monoclonal antibodies in regards to production, lymphocyte differentiation and nomenclature of surface glycoproteins, the advantages and limitations of measuring peripheral blood lymphocyte subsets in selected diseases, in situ identification of lymphocytes in pathologic tissues and the T-cell dual antigen receptors.

Document Type: Research Article

DOI: https://doi.org/10.2500/108854184779063784

Affiliations: Division of Clinical Immunology, Department of Medicine, University of Colorado Medical School

Publication date: 1984-03-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

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    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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