Clinical Impact and Future of Monoclonal Antibodies
In 1975, Köhler and Milstein immortalized single cells producing monoclonal antibody of defined specificity by fusing them with myeloma cells in continuous culture. Since then, the use of monoclonal antibodies has increased exponentially and provided new insights into the cellular interactions involved in immunoregulation. This review will consider monoclonal antibodies in regards to production, lymphocyte differentiation and nomenclature of surface glycoproteins, the advantages and limitations of measuring peripheral blood lymphocyte subsets in selected diseases, in situ identification of lymphocytes in pathologic tissues and the T-cell dual antigen receptors.
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Document Type: Research Article
Affiliations: Division of Clinical Immunology, Department of Medicine, University of Colorado Medical School
Publication date: 01 March 1984
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