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Diagnosis of Immunologic Drug Reactions

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Abstract:

The diagnosis of immunologic drug reactions is frought with difficulties for drugs other than penicillins. A clinical approach is outlined for the problem of deciding which of a number of implicated drugs induced an apparent allergic reaction. Clinically derived information, particularly assessment of the nature and setting of the reaction and consideration of known rates for adverse reactions and immunogenicity, is most often helpful. Immunologic data demonstrating a drug-specific immune response is difficult to obtain without knowledge of the drug's immunochemistry. Incremental provocational testing is definitively useful when an incriminated drug must be re-administered. Premarketing test for immunogenicity of new drugs would greatly facilitate the evaluation and prevention of immunologic drug reactions in the future.

Document Type: Research Article

DOI: https://doi.org/10.2500/108854184779063739

Affiliations: Division of Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine at the Good Samaritan Hospital, Baltimore, Maryland 21239

Publication date: 1984-03-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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