Diagnosis of Immunologic Drug Reactions
The diagnosis of immunologic drug reactions is frought with difficulties for drugs other than penicillins. A clinical approach is outlined for the problem of deciding which of a number of implicated drugs induced an apparent allergic reaction. Clinically derived information, particularly assessment of the nature and setting of the reaction and consideration of known rates for adverse reactions and immunogenicity, is most often helpful. Immunologic data demonstrating a drug-specific immune response is difficult to obtain without knowledge of the drug's immunochemistry. Incremental provocational testing is definitively useful when an incriminated drug must be re-administered. Premarketing test for immunogenicity of new drugs would greatly facilitate the evaluation and prevention of immunologic drug reactions in the future.
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Document Type: Research Article
Affiliations: Division of Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine at the Good Samaritan Hospital, Baltimore, Maryland 21239
Publication date: 1984-03-01
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