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Inhalation Drugs in Asthma Management: State of the Art, Factors Affecting Delivery, and Clinical Response to Inhaled Drugs

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Airway response to inhalation therapy depends on the volume and particle size of the drug being delivered. Factors affecting the particle size of nebulized drugs include driving gas flow rate and pressure, inhalation rate, temperature, and humidity. Inhalation of nebulized saline solutions may cause bronchoconstriction by airway cooling; this may be the mechanism underlying "suggestion-induced" asthma.

Comparative dose-response and direct deposition studies indicate that drug delivery efficiency of a nebulizer is similar to that of a metered dose inhaler and, in consequence, the relatively large recommended dose of nebulized beta-agonist should be reassessed.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854184779063874

Affiliations: Department of Respiratory Medicine, Room ED22, East Wing, Level D, Southampton General Hospital, Tremona Road, Southampton, S09 4XY, Hampshire, England

Publication date: December 1, 1984

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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