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The Effects of Age and Circadian Rhythm on Theophylline Pharmacokinetics in Normal Subjects

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Theophylline metabolism is influenced by a wide variety of biochemical, pathological and environmental factors. These include diet, smoking, other drugs and various disease states. We investigated the effect of advanced age on theophylline disposition. Theophylline clearance rate was higher (43.97 vs 32.97 ml kg−1 hr−1, p<0.001) and the elimination half-life was shorter (6.98 vs 8.14 hr, p<0.02) in the geriatric versus young age group.

We also studied the influence of circadian rhythm on theophylline disposition. In normal male volunteers, age 20-25 yr, there is a significant decrease in the serum theophylline concentration and the area under the serum theophylline concentration-time curve (AUC) during the night. Pharmacokinetic rate constants cannot be considered a priori to be identical for theophylline throughout a 24-hour period.

Document Type: Research Article


Affiliations: Department of Internal Medicine, Division of Allergy and Immunology, University of South Florida College of Medicine, James A. Haley Veterans Administration Hospital, Tampa, Florida

Publication date: 1983-09-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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