Cardiovascular Effects of Theophylline in Chronic Obstructive Pulmonary Disease
Abstract:Theophylline is a widely used bronchodilator in chronic obstructive pulmonary disease (COPD); however, its positive cardiovascular actions have not been recognized widely. In COPD patients with or without cor pulmonale, intravenous aminophylline acutely reduces pulmonary artery pressures and pulmonary vascular resistance while increasing both right and left ventricular ejection fractions. Oral long acting theophylline produces a similar chronic improvement in biventricular performance in patients with COPD. Both reduction in ventricular after load and direct effects of theophylline on ventricular inotropy have been postulated as mechanisms by which this agent augments right and left ventricular ejection fractions. Theophylline may be particularly useful in COPD patients with pulmonary artery hypertension and right or left heart failure.
Document Type: Research Article
Affiliations: Pulmonary Section, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut
Publication date: 1983-09-01
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