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Cardiovascular Effects of Theophylline in Chronic Obstructive Pulmonary Disease

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Theophylline is a widely used bronchodilator in chronic obstructive pulmonary disease (COPD); however, its positive cardiovascular actions have not been recognized widely. In COPD patients with or without cor pulmonale, intravenous aminophylline acutely reduces pulmonary artery pressures and pulmonary vascular resistance while increasing both right and left ventricular ejection fractions. Oral long acting theophylline produces a similar chronic improvement in biventricular performance in patients with COPD. Both reduction in ventricular after load and direct effects of theophylline on ventricular inotropy have been postulated as mechanisms by which this agent augments right and left ventricular ejection fractions. Theophylline may be particularly useful in COPD patients with pulmonary artery hypertension and right or left heart failure.
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Document Type: Research Article

Affiliations: Pulmonary Section, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut

Publication date: 1983-09-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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