Beta Agonists in the Management of Asthma

Author: Dwyer, John M.

Source: Allergy and Asthma Proceedings, Volume 4, Number 3, Summer 1983 , pp. 195-200(6)

Publisher: OceanSide Publications, Inc

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Abstract:

Asthma is a disorder caused by an imbalance in the mechanisms that normally control the constriction and dilation of the bronchial airways. The major defect in the majority of asthmatic subjects involves a lack of normal beta receptor activity allowing normal alpha and cholinergic activity to promote bronchospasm. This condition will be triggered by any number of influences, capitalizing on the basic disorder in the airways. Since the major defect in most asthmatic subjects is a lack of beta receptor activity and therefore a failure to activate biochemical mechanisms that produce cyclic AMP, a logical corrective approach to therapy involves the administration to patients of selective and potent beta2 agonists that will stimulate, pharmacologically, the beta2 receptor and thus supply the AMP needed to produce bronchodilation. The emphasis in using beta2 agonists should be on both the prophylactic use of these agents and their delivery to the patient via his disordered airways. Safety and efficacy are both improved by such an approach.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854183779070408

Affiliations: Section of Clinical Immunology, Yale Medical School

Publication date: June 1, 1983

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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