Calcium Channel Blockers and Obstructive Airway Diseases
The calcium channel blockers are a group of drugs which impede calcium ion entry into cells, thereby inhibiting myocardial and smooth muscle contraction, as well as various secretory processes. In theory, these agents might be active in obstructive airways diseases, especially asthma, by blocking airway smooth muscle constriction, mast cell degranulation, mucous gland secretion, and/or vagal neurotransmission. This report reviews the experimental evidence from animal and human studies, both in vitro and in vivo, that the calcium channel blockers inhibit bronchoconstriction. The usefulness of these drugs in patients with the obstructive airways syndromes remains to be determined by future clinical studies.
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Document Type: Research Article
Affiliations: Harvard Medical School; Brigham and Women's Hospital
Publication date: 1983-03-01
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- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
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