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Calcium Channel Blockers and Obstructive Airway Diseases

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Abstract:

The calcium channel blockers are a group of drugs which impede calcium ion entry into cells, thereby inhibiting myocardial and smooth muscle contraction, as well as various secretory processes. In theory, these agents might be active in obstructive airways diseases, especially asthma, by blocking airway smooth muscle constriction, mast cell degranulation, mucous gland secretion, and/or vagal neurotransmission. This report reviews the experimental evidence from animal and human studies, both in vitro and in vivo, that the calcium channel blockers inhibit bronchoconstriction. The usefulness of these drugs in patients with the obstructive airways syndromes remains to be determined by future clinical studies.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854183779070435

Affiliations: Harvard Medical School; Brigham and Women's Hospital

Publication date: March 1, 1983

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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