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The Role of T-Cell Growth Factor in the Development of Immune Reactivity

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Abstract:

The ability to maintain actively proliferating, antigen specific functional T-cells in suspension culture in vitro has allowed the development of cellular and humoral reagents that can be used to dissect regulation of the T-cell immune response. The T-cell proliferation can be divided into four functionally distinct components: interaction of antigen and macrophage and the resultant production of lymphocyte activating factor (LAF, interleukin 1), action of LAF, production of T-cell growth factor (TCGF, interleukin 2) and action of TCGF. A significant portion of physiological regulation of the immune response is mediated at the levels of production and action of these factors. For example, the immunosuppressive effects of glucocorticosteroids are primarily mediated through suppression of TCGF production. Analogous to other polypeptide hormone systems, agonists and antagonists to the LAF or TCGF production or action will have therapeutic importance in states of either hyperimmune reactivity or immunodeficiency.

Document Type: Research Article

DOI: https://doi.org/10.2500/108854183779070462

Affiliations: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland

Publication date: 1983-03-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

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    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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