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Antihistamines and Decongestants in the Treatment of Chronic Rhinitis

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Antihistamines and decongestants are most effective in chronic non-infectious rhinitides. Chronic rhinitic symptomology includes nasal congestion and pruritus, sneezing, rhinorrhea and "post-nasal" drip. Decongestants are typically thought to decrease congestion by stimulation of alpha adrenergic receptors of the nasal mucosa, while antihistamines decrease the latter symptoms by preventing the mediator effects of released histamine.

Misuse of decongestants and detoxification are perplexing problems facing the clinician, as well as tolerance to antihistamine effect. Anticipation and avoidance of decongestant toxicity in patients with high blood pressure, cardiovascular disease, diabetes, thyroid disease as well as neurological and psychologic drug effects are discussed. Tabulation of currently used single antihistamine and decongestants as well as most commonly used combinations of both are also presented.
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Document Type: Research Article

Publication date: 01 September 1982

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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