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Does the Dog Represent an Animal Model of Asthma?

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Rather than representing a true animal model of asthma, the dog provides a spectrum of airway responsiveness. The most reactive dogs resemble asthmatics in that they demonstrate non-specific bronchial hyper-reactivity. Varying degrees of vagal contribution do not account for the spectrum. Although variations in H2 receptor stimulation and varying degrees of sympatho-adrenal modulation account for some of the spectrum with respect to histamine, these factors do not affect responses to other agents such as methacholine. With regard to allergy, if a narrow spectrum of airway responsiveness is examined, there is a good correlation between skin and airway reactivity to antigen.

Document Type: Research Article


Publication date: September 1, 1981

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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