Does the Dog Represent an Animal Model of Asthma?
Rather than representing a true animal model of asthma, the dog provides a spectrum of airway responsiveness. The most reactive dogs resemble asthmatics in that they demonstrate non-specific bronchial hyper-reactivity. Varying degrees of vagal contribution do not account for the spectrum. Although variations in H2 receptor stimulation and varying degrees of sympatho-adrenal modulation account for some of the spectrum with respect to histamine, these factors do not affect responses to other agents such as methacholine. With regard to allergy, if a narrow spectrum of airway responsiveness is examined, there is a good correlation between skin and airway reactivity to antigen.
Document Type: Research Article
Publication date: 01 September 1981
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