Authors: DeCotiis, Bruce A.; Settipane, Guy A.

Source: Allergy and Asthma Proceedings, Volume 2, Number 3, Summer 1981 , pp. 153-156(4)

Publisher: OceanSide Publications, Inc

Abstract:

Oral and parenteral adrenal corticosteroids have a significant effect on serum immunoglobulins. This effect appears to be sensitive and causes primarily a decrease in serum immunoglobulin G (IgG) and a transient increase in serum immunoglobulin E (IgE). The purpose of this study is to determine if inhaled Beclomethasone causes similar changes in serum immunoglobulins.

Ten asthmatic patients (20% or greater reversibility in FEV₁ after Isoproterenol) and 10 age and sex matched controls were studied. Asthmatic patients were placed on inhaled Beclomethasone (400 μg/day in 4 divided doses) for at least 4 weeks. Blood was drawn on controls without Beclomethasone in a similar time sequence. Serum IgG decreased significantly (10.2% p ≤ 0.018. Wilcoxon matched-pairs signed-ranks test) in the post treatment sera of patients on Beclomethasone, while no significant change was found in the control sera (+1.0%). Eight of the ten asthmatics on Beclomethasone had a net decrease in IgG, one remained unchanged, and one had an increase of 4%. There was no significant change in other immunoglobulins. In summary, Beclomethasone administered in usual doses for 4 weeks appears to produce a significant decrease in serum IgG.

Document Type: Research article

DOI: http://dx.doi.org/10.2500/108854181779134751

Publication date: 1981-06-01

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