The Effect of Inhaled Beclomethasone on Serum Immunoglobulins
Abstract:Oral and parenteral adrenal corticosteroids have a significant effect on serum immunoglobulins. This effect appears to be sensitive and causes primarily a decrease in serum immunoglobulin G (IgG) and a transient increase in serum immunoglobulin E (IgE). The purpose of this study is to determine if inhaled Beclomethasone causes similar changes in serum immunoglobulins.
Ten asthmatic patients (20% or greater reversibility in FEV1 after Isoproterenol) and 10 age and sex matched controls were studied. Asthmatic patients were placed on inhaled Beclomethasone (400 g/day in 4 divided doses) for at least 4 weeks. Blood was drawn on controls without Beclomethasone in a similar time sequence. Serum IgG decreased significantly (10.2% p ≤ 0.018. Wilcoxon matched-pairs signed-ranks test) in the post treatment sera of patients on Beclomethasone, while no significant change was found in the control sera (+1.0%). Eight of the ten asthmatics on Beclomethasone had a net decrease in IgG, one remained unchanged, and one had an increase of 4%. There was no significant change in other immunoglobulins. In summary, Beclomethasone administered in usual doses for 4 weeks appears to produce a significant decrease in serum IgG.
Document Type: Research Article
Publication date: 1981-06-01
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