Skip to main content

The Effect of Inhaled Beclomethasone on Serum Immunoglobulins

Buy Article:

$31.50 plus tax (Refund Policy)

Oral and parenteral adrenal corticosteroids have a significant effect on serum immunoglobulins. This effect appears to be sensitive and causes primarily a decrease in serum immunoglobulin G (IgG) and a transient increase in serum immunoglobulin E (IgE). The purpose of this study is to determine if inhaled Beclomethasone causes similar changes in serum immunoglobulins.

Ten asthmatic patients (20% or greater reversibility in FEV1 after Isoproterenol) and 10 age and sex matched controls were studied. Asthmatic patients were placed on inhaled Beclomethasone (400 g/day in 4 divided doses) for at least 4 weeks. Blood was drawn on controls without Beclomethasone in a similar time sequence. Serum IgG decreased significantly (10.2% p ≤ 0.018. Wilcoxon matched-pairs signed-ranks test) in the post treatment sera of patients on Beclomethasone, while no significant change was found in the control sera (+1.0%). Eight of the ten asthmatics on Beclomethasone had a net decrease in IgG, one remained unchanged, and one had an increase of 4%. There was no significant change in other immunoglobulins. In summary, Beclomethasone administered in usual doses for 4 weeks appears to produce a significant decrease in serum IgG.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Publication date: 1981-06-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Information for Advertisers
  • Reprint Requests
  • www.AJRA.com
  • www.AllergyandRhinology.com
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more