Benefit/Risk Ratio of Aspirin
Abstract:Aspirin is an efficacious drug with increasing medical use. In order to minimize its risk and increase its safety, it should not be used in those high risk individuals with severe asthma, those with steroid-dependent asthma, and those with nasal polyps. I do not believe that it should be indescriminately withheld from all asthmatics, especially those low risk groups with mild extrinsic asthma and no nasal polyps.
Aspirin challenge studies should be done on a double blind-placebo basis with criteria that not only includes pulmonary function tests, but also objective physical signs and symptoms.
Studies of identical twins reveal that when both twins have asthma, only one of the twins may have nasal polyps and aspirin intolerance.
The term aspirin intolerance is vague and should be replaced, perhaps by the term anaphylactoid reactions to aspirin.
Document Type: Research Article
Publication date: 1981-03-01
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