Aspirin sensitivity occurs in 10-30% of asthmatic patients with the higher prevalence in adults with rhinosinusitis. All aspirin sensitive asthmatics who can undergo aspirin challenges can be desensitized to the effects of aspirin. This phenomenon persists for 2-5 days after aspirin is discontinued. Cross-desensitization to nonsteroidal anti-inflammatory drugs also occurs. Potential therapeutic manipulations, using continued aspirin desensitization are currently under study.
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