Effect of Aspirin on Hemostasis and Thrombosis

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Abstract:

Aspirin has its major effect on hemostasis and thrombosis by inhibiting the synthesis of thromboxane A2 by platelets. This is achieved through the irreversible acetylation of the enzyme, platelet cyclooxygenase. Aspirin also inhibits the synthesis of prostaglandin I2 by the vessel wall cells, but this requires a higher dose; and, compared to its effect on platelets, the inhibitory effect on PGI2 production is short-lived.

There is suggestive evidence that aspirin is effective in reducing sudden death in patients who have suffered myocardial infarction and in reducing stroke and death in patients with transient cerebral ischemia. Aspirin, when combined with oral anticoagulants, is more effective than oral anticoagulants alone in preventing systemic embolism in patients with prosthetic heart valves; and, in very low doses, aspirin has been shown to diminish thrombus formation in arteriovenous shunts in patients undergoing chronic hemodialysis.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854181779090903

Publication date: March 1, 1981

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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