Skip to main content

Clinical Pharmacokinetics of Aspirin and Other Salicylates: Implications for Research and Therapy.

Buy Article:

$39.50 plus tax (Refund Policy)

Abstract:

Aspirin undergoes substantial presystemic hydrolysis to salicylic acid following oral administration. Pronounced and apparently consistent interindividual differences in the magnitude of this effect must be taken into consideration in the design of studies to assess the usefulness of aspirin for the prevention of transient cerebral ischemia, stroke, and myocardial infarction. Salicylic acid, which is apparently responsible for the anti-inflammatory effect of aspirin, is subject to capacity-limited elimination due to saturation of two biotransformation pathways, namely formation of salicyluric acid (i.e., conjugation with glycine) and of salicyl phenolic glucuronide. Consequently, the following changes occur as the maintenance dose of a salicylate is increased: steady-state body levels increase more than proportionally, the time to reach steady state increases, and the effects of changes in urinary pH (which affect the renal clearance of salicylic acid) on the body clearance of salicylate become more pronounced. These factors must be taken into consideration in the design of aspirin dosage regimens and in the monitoring and interpretation of plasma salicylate concentrations.

Document Type: Research Article

DOI: https://doi.org/10.2500/108854181779091010

Publication date: 1981-03-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Information for Advertisers
  • Reprint Requests
  • www.AJRA.com
  • www.AllergyandRhinology.com
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more