The Products of the Lipoxygenase Pathway of Arachidonic Acid Metabolism

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Abstract:

Metabolism of arachidonic acid by lipoxygenase in inflammatory cells and lung tissue results in the production of a number of hydroperoxy- and hydroxyeicosatetraenoic acids (HPETEs and HETEs respectively) and leukotrienes. Leukotrienes C4(LTC4) and D4(LTD4) are bronchoconstrictors and increase vascular permeability. Lipoxygenase inhibitors block leukotriene synthesis, and thereby reduce prolonged allergic bronchoconstriction and indomethacin-induced airways hyperreactivity. HPETEs and HETE attract neutrophils and eosinophils to inflammatory sites. Lipoxygenase inhibitors reduce HPETE and HETE synthesis and suppress chemotaxis and chemokinesis of neutrophils and eosinophils induced by inflammatory stimuli. Lipoxygenase inhibitors are therefore potential anti-asthmatic and anti-inflammatory agents.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854181779090967

Publication date: March 1, 1981

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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