Skip to main content

Arachidonic Acid Cascade: The Cyclooxygenase Pathway

Buy Article:

$39.50 plus tax (Refund Policy)


Arachidonic acid present in cell membranes is enzymatically converted to prostaglandins of varying biologic activity, depending upon cell type, by the cyclooxygenase pathway. Prostacyclin (PGI2) synthesized by vascular endothelium, and thromboxane A2 (TXA2), synthesized by platelets, have opposing modulatory effects upon hemostasis and vascular tone. The balance between these prostaglandins is affected by plasma factors, availability of arachidonate as substrate, and rates of enzyme inactivation. Aspirin has profound effects upon prostaglandin synthesis by irreversibly acetylating the pivotal enzyme cyclooxygenase, leading to therapeutically useful changes in PGI2-TXA2 interactions.

Document Type: Research Article


Publication date: March 1, 1981

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Information for Advertisers
  • Reprint Requests
  • ingentaconnect is not responsible for the content or availability of external websites

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more
Real Time Web Analytics