Suppressor T cells in man
Abstract:It is clear from the above review that suppressor cells are present in normal individuals and that a deficiency in suppressor cells accompanies a number of diseases in which there is evidence of autoreactivity. These diseases have in common a deficiency in suppressor T cells but have different targets of autoaggression. In the case of systemic lupus, the target is the DNA and other antigens from the cells against which autoantibodies are made. In the case of graft versus host reaction and atopic dermatitis, it is the fibroblasts of the skin. In the case of allergic disease, it is the regulation of the IgE response. On the other hand, excess of suppressor cells either primary or secondary can result in aberrations of immunoregulation resulting in secondary immunodeficiency such as in some cases of acquired common variable agammaglobulinemia and in infectious mononucleosis.
It is hoped that the acquisition of information on suppressor cells would permit strategies to modulate their function in vivo which should be helpful in the treatment of diseases in which a lack of an over production of suppressor cells are impeded.
Document Type: Research Article
Publication date: September 1, 1980
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