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Suppressor T cells in man

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It is clear from the above review that suppressor cells are present in normal individuals and that a deficiency in suppressor cells accompanies a number of diseases in which there is evidence of autoreactivity. These diseases have in common a deficiency in suppressor T cells but have different targets of autoaggression. In the case of systemic lupus, the target is the DNA and other antigens from the cells against which autoantibodies are made. In the case of graft versus host reaction and atopic dermatitis, it is the fibroblasts of the skin. In the case of allergic disease, it is the regulation of the IgE response. On the other hand, excess of suppressor cells either primary or secondary can result in aberrations of immunoregulation resulting in secondary immunodeficiency such as in some cases of acquired common variable agammaglobulinemia and in infectious mononucleosis.

It is hoped that the acquisition of information on suppressor cells would permit strategies to modulate their function in vivo which should be helpful in the treatment of diseases in which a lack of an over production of suppressor cells are impeded.
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Document Type: Research Article

Publication date: 01 September 1980

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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