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Differential Effects of Histamine and SRS-A on Airway Function: In Vivo and In Vitro

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The effects of histamine and a partially purified preparation of slow-reacting substance of anaphylaxis (SRS-A) on pulmonary mechanics in the guinea pig in vivo and on tissue strip contractile responses in vitro were compared. On the basis of the in vivo data, it was suggested that SRS-A compared to histamine may have selective activity on peripheral airways. This hypothesis was tested by an in vitro evaluation of the contractile responses of tracheal spirals and parenchymal strips to histamine and SRS-A. In this test system, SRS-A when compared to histamine was also found to have selective activity on more peripheral airways, as indicated by parenchymal strip constriction.

Document Type: Research Article

Publication date: 1980-06-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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