Highly similar noncoding genomic DNA sequences: ultraconserved, or merely widespread?

Author: Hickey, Donal A.

Source: Genome, Volume 51, Number 5, May 2008 , pp. 396-397(2)

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Abstract:

In this note, I propose an explanation for the seeming contradiction between bioinformatics-based predictions of an essential function for ultraconserved DNA sequences, and the lack of an experimental demonstration of such function.

Dans cette note, l'auteur propose une explication pour l'apparente contradiction entre les prédictions fondées sur la bio-informatique voulant que les séquences d'ADN ultraconservées aient une fonction essentielle et l'absence d'appui empirique pour une telle fonction.

Document Type: Research article

Publication date: 2008-05-01

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From its inception in 1957, this international cytogenetics journal has catered to the research areas of the members of the Genetics Society of Canada; traditionally, these have included agriculture, entomology, genetics/cytogenetics, and evolutionary mechanisms. The contents of the journal have evolved as contributors developed new technologies and interests. A 20-member Editorial Board is composed of scientists from around the world. Reviews and commentary from respected experts are often featured.
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