A surprising abundance of human disease genes in a simple “basal” animal, the starlet sea anemone (Nematostella vectensis)

Authors: Sullivan, James C.; Finnerty, John R.

Source: Genome, Volume 50, Number 7, 1 July 2007 , pp. 689-692(4)

Publisher: NRC Research Press

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Abstract:

Invertebrate animals have provided important insights into the mechanisms of, and treatment for, numerous human diseases. A surprisingly high proportion of genes underlying human disease are present in the genome of a simple, evolutionarily basal invertebrate animal, Nematostella vectensis, including some genes that are absent in established invertebrate model organisms. This, together with the laboratory tractability and regenerative capability of N. vectensis, recommends the species as an important new experimental model for the study of genes underlying human disease.

Les invertébrés ont permis des découvertes importantes en ce qui a trait aux mécanismes et au traitement de nombreuses maladies humaines. Une proportion étonnamment élevée des gènes responsables de pathologies humaines est présente au sein du génome d'un simple invertébré basal sur le plan évolutif, Nematostella vectensis, incluant certains gènes qui sont absents chez les invertébrés modèles. Combiné avec l'aptitude du N. vectensis à l'élevage et à la régénération en laboratoire, cela suggère que le N. vectensis constituerait un important nouveau modèle expérimental pour l'étude des gènes causant des pathologies humaines.

Document Type: Research article

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