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Morphine uptake, disposition, and analgesic efficacy in the common goldfish (Carassius auratus)

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The purposes of the present study were to examine the rate of morphine uptake in goldfish (Carassius auratus (L., 1758)) when administered via the water, to calculate the pharmacokinetics of morphine when administered intraperitoneally, and to determine whether morphine could act as an analgesic. When administered via the water, morphine uptake was very slow, and the concentration accumulated in the plasma was <1% of that in water after 2 h. Furthermore, changing water pH or hardness caused small changes in morphine uptake from the water, but plasma levels remained <1% of water concentrations after 2 h exposure. The pharmacokinetics of morphine administered intraperitoneally (40 mg/kg) revealed a half-time for elimination of 37 h and a mean residence time of 56 h. Finally, morphine acted as an analgesic when administered via the water as demonstrated by significantly decreased rubbing behaviour in response to the presence of a noxious stimulus (subcutaneous injection of 0.7% acetic acid). Although morphine appeared to have analgesic properties in goldfish, morphine administered via ambient water is not recommended because of its slow rate of uptake.

Les objectifs de notre étude sont d’examiner chez le cyprin doré (Carassius auratus (L., 1758)) le taux d’absorption de la morphine administrée par voie aqueuse, de calculer la pharmacocinétique de la morphine par administration intrapéritonéale et de déterminer si la morphine peut servir d’analgésique. Administrée par voie aqueuse, la morphine est absorbée très lentement et la concentration plasmatique représente moins de 1 % de celle de l’eau après 2 h. De plus, des modifications du pH ou de la dureté de l’eau causent de petits changements dans l’absorption de la morphine à partir de l’eau, mais les concentrations plasmatiques demeurent inférieures à 1 % des concentrations aqueuses après une exposition de 2 h. La pharmacocinétique de la morphine administrée par voie intrapéritonéale (40 mg/kg) indique une demi-vie d’élimination de 37 h et un temps de séjour moyen de 56 h. Enfin, la morphine administrée par voie aqueuse agit comme analgésique; en effet, le comportement de frottement est réduit de façon significative en réaction à la présence d’un stimulus nocif (injection sous-cutanée d’acide acétique à 0,7 %). Bien que la morphine semble avoir des vertus analgésiques chez le cyprin doré, il n’est pas recommandé d’administrer la morphine par voie aqueuse à cause de son taux lent d’absorption.

Document Type: Research Article

Publication date: 2009-05-01

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  • Published since 1929, this monthly journal reports on primary research contributed by respected international scientists in the broad field of zoology, including behaviour, biochemistry and physiology, developmental biology, ecology, genetics, morphology and ultrastructure, parasitology and pathology, and systematics and evolution. It also invites experts to submit review articles on topics of current interest.
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