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Acute phase nematode infection reduces resting metabolic rate in both protein-sufficient and protein-deficient mice

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The objective of this study was to investigate whether protein deficiency concurrent with the acute phase of infection with the murine nematode Heligmosomoides bakeri (Durette-Desset, Kinsella and Forrester, 1972; Tenora and Barus, 2001) affected the resting metabolic rate (RMR) in BALB/c mice, and whether deworming caused RMR to return to normal. Mice fed either a protein-sufficient (PS, 24%) or protein-deficient (PD, 3%) diet were infected with 100 larvae, and then treated with an anthelmintic drug on 9 and 14 days postinfection (dpi). RMR was measured on -2, 2, 7, and 19 dpi. The results showed that protein deficiency did not affect RMR at any of these times. RMR was unchanged immediately following infection (2 vs. -2 dpi) at the time when larvae are first embedded in the serosal musculture. Surprisingly, at 7 dpi when larvae migrate from the serosal musculture into the intestinal lumen, RMR was significantly lower in both diet groups compared with earlier time points. This reduced RMR persisted even after deworming. Possible reasons for these results are discussed.

L’objectif de notre travail est d’examiner si la carence protéique associée à la phase aiguë de l’infection au nématode murin Heligmosomoides bakeri (Durette-Desset, Kinsella et Forrester, 1972; Tenora and Barus, 2001) affecte le taux de métabolisme de repos (RMR) chez des souris BALB/c et si le traitement vermifuge produit un retour du RMR à la normale. Des souris nourries d’un régime adéquat (PS, 24 %) ou déficient (PD, 3 %) en protéines ont été infectées avec 100 larves et traitées ensuite avec un médicament anthelminthique aux jours 9 et 14 après l’infection (dpi). Le RMR a été mesuré aux jours -2, 2, 7 et 19 dpi. La carence protéique n’affecte pas le RMR en aucun de ces moments. Le RMR reste inchangé immédiatement après l’infection (jour 2 par rapport au jour -2) au moment où les larves pénètrent pour la première fois dans la musculature de la séreuse. Étonnamment, au jour 7 lorsque les larves migrent de la musculature de la séreuse vers la lumière de l’intestin, le RMR est significativement plus bas dans les deux groupes alimentaires expérimentaux par comparaison aux périodes précédentes. Ce RMR réduit persiste même après le traitement vermifuge. Nous discutons des raisons possibles qui expliquent ces résultats.

Document Type: Research Article

Publication date: December 1, 2008

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  • Published since 1929, this monthly journal reports on primary research contributed by respected international scientists in the broad field of zoology, including behaviour, biochemistry and physiology, developmental biology, ecology, genetics, morphology and ultrastructure, parasitology and pathology, and systematics and evolution. It also invites experts to submit review articles on topics of current interest.
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