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Is prolactin responsible for avian, saurian, and mammalian relapse and periodicity of fever in malarial infections?

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P.C.C. Garnham came to Toronto nearly 35 years ago to see if he, and the laboratory of A.M. Fallis, could unravel the enigma of "relapsing" malaria-like infections in migrating ducks (to Algonquin Park, Ontario). At the time, not enough was known about the endocrinology of avian migration and reproduction. Now a growing body of indirect evidence seems to point to a role for prolactin in many of the uniquely pathologic phenomena witnessed in malarial infections. Arguments in favour of the involvement of prolactin, as both a developmental hormone and a proinflammatory cytokine, in the pathology of relapse, fever, anaemia, and maternal malaria are presented in the hope that experiments to test such involvement will be designed.

P.C.C. Garnham est venu à Toronto, il y a bientôt 35 ans, dans l'espoir de pouvoir, avec le concours du laboratoire d'A.M. Fallis, résoudre l'énigme des infections récurrentes de type malarien chez les canards migrateurs (au Parc Algonquin, Ontario). À l'époque, l'endocrinologie de la migration et de la reproduction des oiseaux était encore mal connue. Aujourd'hui, une accumulation de preuves indirectes semble indiquer que la prolactine joue un rôle dans les phénomènes pathologiques particuliers associés aux infections malariennes. On donne ici des arguments en faveur de l'intervention de la prolactine, aussi bien comme hormone de développement que comme cytokine pro-inflammatoire, dans la pathologie des rechutes, de la fièvre, de l'anémie et de la malaria maternelle, dans le but de susciter la création de tests propres à évaluer ce rôle.[Traduit par la Rédaction]

Document Type: Research Article

Publication date: 2002-07-01

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  • Published since 1929, this monthly journal reports on primary research contributed by respected international scientists in the broad field of zoology, including behaviour, biochemistry and physiology, developmental biology, ecology, genetics, morphology and ultrastructure, parasitology and pathology, and systematics and evolution. It also invites experts to submit review articles on topics of current interest.
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