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Parturition in Anodonta cygnea induced by selective serotonin reuptake inhibitors (SSRIs)

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The selective serotonin reuptake inhibitors (SSRIs) fluoxetine (Nodep) and fluvoxamine (Dumyrox) are drugs commonly prescribed for the treatment of depression in humans. They act to increase serotonin (5-hydroxytryptamine) neurotransmission by inhibiting reuptake transport proteins at synapses. A similar effect of SSRIs seems to occur naturally in one group of invertebrates, the molluscs. In this study the action of these drugs at different concentrations and under different conditions was tested in the freshwater mussel Anodonta cygnea. Fluoxetine was more potent than fluvoxamine, inducing an intense release of larvae (parturition) at a concentration of 1 × 10–6 M in the presence of light. The non-SSRI antidepressants trazodone (Triticum), mianserine (Tolvon), and L-5-hydroxytryptophan (Cincofarm), which are known to have different serotoninergic mechanisms, had a strong, no, and a weak effect, respectively, on larval parturiton in A. cygnea. These effects suggest that serotonin could be a normal and relevant mediator of larval parturition in A. cygnea. Other parallel visible signs due to incubation with SSRIs were an increase in the volume of the foot and gills through water uptake and stimulation of valve movements. These results indicate that incubation with SSRIs is potentially important in culturing the larvae of freshwater bivalves, since it facilitates control of the intensity and timing of larval parturition.

Les inhibiteurs sélectifs du recaptage de la sérotonine (SSRIs) la fluoxetine (« Nodep ») et la fluvoxamine (« Dumyrox ») sont prescrits fréquemment pour traiter la dépression chez les humains. Ils agissent en favorisant la neurotransmission de la sérotonine (5-hydroxytrypamine) par inhibition des protéines de transport aux synapses. Les SSRIs semblent avoir un effet similaire naturel chez les invertébrés, notamment chez les mollusques. Nous avons vérifié l'effet de ces inhibiteurs à différentes concentrations et dans plusieurs types de conditions chez Anodonta cygnea. La fluoxetine est plus efficace que la fluvoxamine comme déclencheur de la libération des larves (parturition) à une concentration de 1 × 10–6 M, en présence de lumière. Les antidépresseurs autres que les SSRI, connus par différents mécanismes sérotonergiques, ont des effets différentiels sur la parturition d'A. cygnea, la trazodone (« Triticum ») a une action très marquée, la mianserine (« Tolvon ») n'a aucun effet et le L-5-hydroxytryptophane (« Cincofarm » ) a peu d'effet. Ces résultats semblent indiquer que la sérotonine pourrait être un médiateur normal et important de la parturition chez A. cygnea. L'incubation dans les SSRIs est également responsable d'autres signes visibles, l'augmentation de volume du pied et des branchies par absorption d'eau et la stimulation des mouvements des valves. Ces résultats indiquent que l'incubation dans les SSRIs peut être avantageuse pour la culture des larves de bivalves d'eau douce puisqu'elle facilite le contrôle de l'importance et du moment de la production de larves.[Traduit par la Rédaction]

Document Type: Research Article

Publication date: January 1, 2001

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  • Published since 1929, this monthly journal reports on primary research contributed by respected international scientists in the broad field of zoology, including behaviour, biochemistry and physiology, developmental biology, ecology, genetics, morphology and ultrastructure, parasitology and pathology, and systematics and evolution. It also invites experts to submit review articles on topics of current interest.
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