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Cell therapy in the heart

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Abstract:

Cell therapy is emerging as a new strategy to circumvent the adverse effects of heart disease. Many experimental and clinical studies investigating the transplantation of cells into the injured myocardium have yielded promising results. Moreover, data from these reports show that transplanted stem cells can engraft within the myocardium, differentiate into major cardiac cell types, and improve cardiac function. However, results from clinical trials show conflicting results. These trials demonstrate significant improvements in cardiac function for up to 6 months. However, these improved functions were diminished when examined at 18 months. In this review, we will discuss the current literature available on cell transplantation, covering studies ranging from animal models to clinical trials.

Keywords: adult and embryonic stem cells; cardiac myocytes; cardiomyopathie; cardiomyopathy; cell transplantation therapy; cellules souches adultes et embryonnaires; clinical trials; essais cliniques; myocytes cardiaques; thérapie cellulaire

Document Type: Research Article

DOI: https://doi.org/10.1139/y11-130

Affiliations: Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.

Publication date: 2012-03-16

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  • Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership.
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