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Cellular plasticity: the good, the bad, and the ugly? Microenvironmental influences on progenitor cell therapy

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Abstract:

Progenitor cell based therapies have emerged for the treatment of ischemic cardiovascular diseases where there is insufficient endogenous repair. However, clinical success has been limited, which challenges the original premise that transplanted progenitor cells would orchestrate repair. In this review, we discuss the basics of endothelial progenitor cell therapy and describe how microenvironmental changes (i.e., trophic and mechano-structural factors) in the damaged myocardium influence progenitor cell plasticity and hamper beneficial therapeutic outcome. Further understanding of these microenvironmental clues will enable optimization of cell therapy at all levels. We discuss current concepts and provide future perspectives for the enhancement of progenitor cell therapy, and merge these advances into a combined approach for ischemic tissue repair.

Keywords: cardiovascular disease; cell therapy; cellule progénitrice endothéliale; contrainte de cisaillement; cyclic strain; déformation cyclique; endothelial progenitor cell; endothelial–mesenchymal transition; fluid shear stress; inflammation; maladie cardiovasculaire; mechanotransduction; microenvironment; microenvironnement; mécanotransduction; plasticity; plasticité; thérapie cellulaire; transition endothélium–mésenchyme

Document Type: Research Article

DOI: http://dx.doi.org/10.1139/y11-107

Publication date: March 16, 2012

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  • Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership.
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