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Effects of imidazolines on neurogenic contraction in isolated urinary bladder detrusor strips from rabbit

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Abstract:

Moxonidine and clonidine, which are imidazoline compounds, are sympathetic modulators used as centrally acting antihypertensive drugs. Moxonidine, clonidine, and agmatine produce extensive effects in mammalian tissues via imidazoline recognition sites (or receptors) or α2-adrenoceptors. To investigate the effects of imidazolines on the function of the urinary bladder, we tested the effects of moxonidine, clonidine, and agmatine on the neurogenic contraction induced by electric field stimulation, and on the post-synaptic receptors in isolated urinary bladder detrusor strips from rabbit. Both moxonidine at 1.0–10.0 µmol/L and clonidine at 0.1–10.0 µmol/L inhibited electric-field-stimulation-induced contraction in a concentration-dependent manner, but not agmatine (10.0–1000.0 µmol/L). Both moxonidine and clonidine failed to affect carbachol or adenosine-triphosphate-induced contractions; however, 1000.0 µmol/L agmatine significantly increased these contractions. Our study indicates that (i) moxonidine and clonidine produce a concentration-dependent inhibition of the neurogenic contractile responses to electric field stimulation in isolated detrusor strips from male New Zealand rabbits; (ii) post-synaptic muscarinic receptor and purinergic receptor stimulation are not involved in the responses of moxinidine and clonidine in this study; (iii) the inhibitory effects of these agents are probably not mediated by presynaptic imidazoline receptors.

Keywords: adrénorécepteurs-α2; agmatine; clonidine; electric field stimulation; imidazoline recognition site; imidazolines; lapin; moxonidine; rabbit; site de reconnaissance des imidazolines; stimulation de champ électrique; urinary bladder; vessie; α2-adrenoceptor

Document Type: Research Article

DOI: https://doi.org/10.1139/y11-112

Affiliations: 1: School of Pharmacy, Hebei Medical University, 361 East Zhong-shan Road, Shijiazhuang 050017, Hebei, P.R. China. 2: Department of Pharmacology, School of Medicine, Hebei University of Engineering, Handan 056029, Hebei, P.R. China. 3: Hebei Professional College in Chemical & Pharmaceutical Sciences, Shijiazhuang 050031, Hebei, P.R. China.

Publication date: 2012-02-20

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