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Therapeutic efficacy of Hypericum perforatum L. extract for mice infected with an influenza A virus

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Abstract:

Hypericum perforatum L., a plant used in Chinese herbal medicine, has been proven effective against many viral diseases. In the present study, the therapeutic efficacy of an extract of H. perforatum (HPE) against influenza A virus (IAV) was investigated in mice. Whether HPE would be a promising agent for influenza treatment was evaluated by measuring the protection rate, mean survival days, lung index, and viral titer, as well as the secretion of IL-6, interleukin-10 (IL-10), tumour necrosis factor-α (TNF-α), and interferon-gamma (IFN-γ) in lung tissue and serum on days 3 and 5 post-infection. The results showed that HPE could reduce the lung index and viral titer of mice infected with IAV, decrease mortality, and prolong the mean survival time. HPE decreased the concentration of IL-6 and TNF-α in lung tissue and serum on day 5 post-infection. In contrast, HPE enhanced the lung and serum levels of IL-10 and IFN-γ on the days 3 and 5 post-infection. Our study indicates that HPE has significant therapeutic efficacy for mice infected with IAV. The possible reasons for these results were concluded to be pertaining to up-regulating the expression of IL-10 and IFN-γ, and down-regulating the secretion of IL-6 and TNF-α in lung and serum.

Keywords: Hypericum perforatum L. extract (HPE); cytokine; efficacité thérapeutique; extrait de Hypericum perforatum L. (HPE); influenza A virus (IAV); therapeutic efficacy; virus grippal A (VGA)

Document Type: Research Article

DOI: http://dx.doi.org/10.1139/y11-111

Affiliations: 1: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China, NO. 287 Langongping Street, Qilihe district, Lanzhou city, 730050, Gansu province, China. 2: Key Laboratory of New Animal Drug Project of Gansu Province/Key Laboratory of New Animal Drug Project of CAAS, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China. 3: Inner Mongolia University for The Nationalities, Tongliao 028043, China.

Publication date: February 20, 2012

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  • Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership.
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