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Redox regulation of stem cell mobilization

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Abstract:

A growing body of evidence supports the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)-1α appears to play a significant role in their maintenance and homing mechanism.

Un nombre croissant de preuves appuie le rôle de la signalisation redox dans la mobilisation des cellules souches hématopoïétiques et homing mécanisme. Cytokines et des molécules d’adhésion de contrôle de mobilisation de cellules souches dans le cadre d’un processus d’oxydoréduction réglementés. FoxO-SirT réseau semble être étroitement impliqué dans redox réglementé l’homéostasie des cellules souches alors que leur processus de différenciation est régulée par des protéines redox factor-1 (Ref-1). Le manque d’oxygène (hypoxie), précisément contrôlée hypoxie peut stimuler la croissance des cellules souches dans leur niche et de HIF-1 semble jouer un rôle significatif dans leur maintien et homing mécanisme.

Document Type: Research Article

Publication date: December 1, 2009

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  • Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership.
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