Authors: Cimbaljević, Branko; Vasilijević, Ana; Cimbaljević, Slavica; Buzadžić, Biljana; Korać, Aleksandra; Petrović, Vesna; Janković, Aleksandra; Korać, Bato

Source: Canadian Journal of Physiology and Pharmacology, Volume 85, Number 10, October 2007 , pp. 997-1003(7)

Publisher: NRC Research Press

Abstract:

This study aimed to investigate the interrelationship of plasma lipid profile, lipid peroxidation, and erythrocyte antioxidative defense in patients with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. Plasma levels of total cholesterol, triglycerides, and lipid peroxides and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase (GSH-Px), as well as the amount of glutathione in erythrocytes, were determined in IDDM, NIDDM, and nondiabetic control subjects. Additionally, morphology of erythrocytes in all subjects was examined. Plasma levels of total cholesterol and triglycerides were significantly increased in NIDDM compared with controls. Also, the lipid peroxide level was higher in NIDDM than in either control or IDDM subjects. CuZnSOD activity in erythrocytes was elevated in NIDDM patients compared with the control. In NIDDM patients, more extensive erythrocyte spherocytosis and echinocytosis compared with both control and IDDM subjects were observed. In contrast with the IDDM group, the observed abnormality in lipid metabolism in NIDDM patients is closely associated with increased lipid peroxidation, changes in antioxidative defense, and erythrocyte morphology.

La présente étude a eu pour objectif d'examiner la relation entre le profil lipidique, la peroxydation lipidique et la défense antioxydative des érythrocytes dans le plasma chez les patients souffrant de diabète insulinodépendant (DID) et de diabète non insulinodépendant (DNID). On a déterminé les taux plasmatiques de cholestérol total, de triglycérides et de peroxydes lipidiques, les activités de la superoxyde dismutase cuivre/zinc (SOD Cu/Zn), de la catalase et de la glutathion peroxydase (GSH-Px) ainsi que le taux de glutathion (GSH) dans les érythrocytes chez des sujets DID, DNID et témoins non diabétiques sains. On a aussi examiné la morphologie des érythrocytes de tous les sujets. Les taux plasmatiques de cholestérol total et de triglycérides ont augmenté significativement chez les DNID compartiment à ceux des sujets sains. De plus, le taux de peroxydes lipidiques a été plus élevé chez les sujets DNID que chez les sujets DID et sains. L'activité SOD Cu/Zn dans les érythrocytes était élevée chez les DNID comparativement à celle des témoins. Les sujets DNID ont présenté une sphérocytose et une échinocytose plus étendues des érythrocytes que les sujets DID et témoins. L'anormalité observée dans le métabolisme des lipides des sujets DNID, contrairement à celle des sujets DID, est étroitement associée à l'augmentation de la peroxydation lipidique, aux modifications de ladéfense antioxydative et à la morphologie des érythrocytes.

Document Type: Research article

Publication date: 2007-10-01

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