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The role of Granzyme B in atheromatous diseases

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Abstract:

The mechanism and role of apoptotic cell death in the pathogenesis of atheromatous diseases is an area of intense research. Atherosclerosis is an inflammatory disease and as such, immune-mediated cell killing plays an important role. Recent studies have suggested that Granzyme B and perforin play an important role in atherogenesis. The current manuscript reviews our current understanding pertaining to the role of Granzyme B in cardiac allograft vasculpathy and atherosclerosis.

Le mécanisme et le rôle de la mort apoptotique cellulaire dans la pathogenèse des maladies athéromateuses constituent un domaine de recherche intense. L'athérosclérose est une maladie inflammatoire; par conséquent, la mort cellulaire à médiation immunitaire joue un rôle important. De récentes études ont donné à penser que la Granzyme B et la perforine jouent un rôle fondamental dans l'athérogenèse. Le présent document présente une synthèse de notre compréhension actuelle du rôle de la Granzyme B dans la vasculopathie du greffon cardiaque et l'athérosclérose.

Document Type: Research Article

Publication date: January 1, 2007

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  • Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership.
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