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Neuropeptide Y (NPY) and NPY receptors in the cardiovascular system: implication in the regulation of intracellular calcium

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The 3-dimensional confocal microscopy technique has allowed us to identify the presence of yet another cardioactive factor and its receptor, namely neuropeptide Y (NPY) and its Y1 receptor, at the level of vascular smooth muscle cells and heart cells including endocardial endothelial cells (EECs). Using this technique, we also demonstrated that NPY is able to induce an increase in both cytosolic and nuclear calcium in all these cell types. Furthermore, besides being expressed at the level of EECs, NPY is also released from these cells following a sustained increase of intracellular Ca2+. This suggests the ability of NPY to contribute to the regulation of the excitation–secretion coupling of EECs and the excitation–contraction coupling of cardiomyocytes and vascular smooth muscle cells.

La microscopie confocale tridimensionnelle nous a permis d’identifier la présence d’un autre facteur cardioactif et de son récepteur, à savoir le NPY et son récepteur Y1, au niveau des cellules musculaires lisses vasculaires et des cellules cardiaques, y compris les cellules endothéliales endocardiques (CEE). À l’aide de cette technique, nous avons aussi démontré que le NPY peut induire une augmentation du calcium cytosolique et nucléaire dans tous ces types de cellules. De surcroît, en plus d’être exprimé au niveau des CEE, le NPY est aussi libéré de ces cellules après une augmentation soutenue du Ca2+ intracellulaire. Ces observations laissent supposer que le NPY contribue à la régulation du couplage excitation–sécrétion des CEE et au couplage excitation–contraction des cardiomyocytes et des cellules musculaires lisses vasculaires.

Document Type: Research Article

Publication date: 2007-01-01

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  • Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership.
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