Protective effects of polysaccharide from Euphorbia kansui (Euphorbiaceae) on the swimming exercise-induced oxidative stress in mice

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Abstract:

The present study examined the effects of derivatives of galactosides and glucosides in a polysaccharide extract from Euphorbia kansui (Euphorbiaceae) on exercise-induced oxidative stress in mice. Exhaustive swimming exercise significantly increases the degree of lipid peroxidation in terms of malondialdehyde content and reduces the antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Our findings revealed that chronic oral treatment with the extract elevates enzymatic activities of SOD and GPx accompanied by a corresponding decrease in malondialdehyde. The antioxidative activities of these compounds against exercise-induced oxidative stress are correlated with various activities such as reducing the production of superoxide and hydroxyl radicals, inhibiting lipid peroxidation, enhancing antioxidative defenses, and increasing the production of SOD and GPx activity and expression in different tissues. These compounds may be involved in glycogen metabolism to meet the requirement of working skeletal muscles and act as antioxidants by terminating the chain reaction of lipid peroxidation to maintain the morphological stability of mitochondria in spinal motor neurons. These observations suggest that E. kansui has antioxidative and antifatigue properties and can be given as prophylactic and (or) therapeutic supplements for increasing antioxidant enzyme activities and preventing lipid peroxidation during strenuous exercise.

La présente étude a examiné les effets de dérivés de galactosides et de glucosides dans un extrait de polysaccharide de Euphorbia kansui (Euphorbiacées) sur le stress oxydatif induit par l’exercice chez les souris. Un exercice intense en piscine augmente significativement le degré de peroxydation lipidique en termes de teneur en malondialdéhyde et réduit les activités antioxydantes de la superoxyde dismutase (SOD) et de la glutathion peroxydase (GPx). Nos résultats ont révélé qu’un traitement oral chronique avec l’extrait pourrait augmenter les activités enzymatiques de la SOD et de la GPx et diminuer simultanément la teneur en MDA. Les activités antioxydantes de ces composés contre le stress oxydatif induit par l’exercice sont corrélées avec diverses activités telles que la réduction de la production des radicaux superoxyde et hydroxyl, l’inhibition de la peroxydation lipidique, la stimulation des défenses antioxydantes ainsi que l’augmentation de la production de l’expression et de l’activité de la SOD et de la GPx dans divers tissus. Ces composés pourraient participer au métabolisme du glycogène pour répondre aux besoins des muscles squelettiques au travail, et agir comme antioxydants en interrompant la réaction en chaîne de la peroxydation lipidique pour maintenir la stabilité morphologique des mitochondries dans les neurones moteurs spinaux. Ces observations donnent à penser que E. kansui a des propriétés antioxydantes et antifatigue et qu’il peut être administré comme supplément prophylactique/thérapeutique pour augmenter les activités enzymatiques antioxydantes et prévenir la peroxydation lipidique durant un exercice intense.

Document Type: Research Article

Publication date: October 1, 2006

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  • Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership.
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