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Asynchronous calcium waves in smooth muscle cells

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Abstract:

Asynchronous Ca2+ waves or wave-like [Ca2+]i oscillations constitute a specialized form of agonist-induced Ca2+ signaling that is observed in a variety of smooth muscle cell types. Functionally, it is involved in the contractile regulation of the smooth muscle cells as it signals for tonic contraction in certain smooth muscle cells while causing relaxation in others. Mechanistically, repetitive Ca2+ waves are produced by repetitive cycles of sarcoplasmic reticulum Ca2+ release followed by Ca2+ uptake. Plasmalemmal Ca2+ entry mechanisms are important for providing the additional Ca2+ necessary to maintain proper refilling of the sarcoplasmic reticulum Ca2+ store and support ongoing Ca2+ waves. In this paper, we will review the phenomenon of asynchronous Ca2+ waves in smooth muscle and discuss the scientific and clinical significance of this new understanding.Key words: excitation-contraction coupling, confocal fluoresence microscopy, calcium signaling.

Les ondes de Ca2+ asynchrones ou les oscillations de [Ca2+]i de type ondes constituent une forme spécialisée de signalisation du Ca2+ induite par des agonistes, qui est observée dans une variété de types de cellules musculaires lisses. Sur le plan fonctionnel, elle participe à la régulation contractile des cellules musculaires lisses, en commandant la contraction tonique dans certaines cellules et en induisant la relaxation dans d'autres. En ce qui a trait aux mécanismes, les ondes de Ca2+ répétitives sont produites par des cycles répétitifs de libération du Ca2+ du réticulum sarcoplasmique suivie de sa recapture. Les mécanismes d'entrée du Ca2+ dans la membrane plasmique sont importants pour fournir le Ca2+ additionnel nécessaire au maintien du remplissage approprié de la réserve de Ca2+ du réticulum sarcoplasmique et soutenir les ondes de Ca2+ en cours. Dans cet article, nous réviserons le phénomène des ondes de Ca2+ asynchrones dans le muscle lisse et nous discuterons de l'importances scientifique et clinique de ce nouvel éclairage.Mots clés : couplage excitation-contraction, microscopie confocale, signalisation calcique.[Traduit par la Rédaction]

Document Type: Research Article

Publication date: August 1, 2005

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  • Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership.
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