Cells, cytokines and cellular immunity in the pathogenesis of fibroproliferative vasculopathies

Authors: Mitra, Amit K; Del Core, Michael G; Agrawal, Devendra K

Source: Canadian Journal of Physiology and Pharmacology, Volume 83, Numbers 8-9, August 2005 , pp. 701-715(15)

Publisher: NRC Research Press

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Abstract:

Atherosclerosis and restenosis are the result of vascular injury followed by an inflammatory and fibroproliferative response that involves a large number of growth factors, cytokines, and cellular elements. Platelet activation and leukocyte recruitment into the arterial intima play a crucial role, initiating a whole spectrum of reactions leading to vascular smooth muscle cell hyperplasia and intimal migration. The roles of macrophages and lymphocytes and mast cells as mediators of inflammation and immune response is discussed, as are the roles of growth factors and cytokines. New light on the 'old' problems will help us to devise newer and better therapeutic strategies to combat these clinical entities.Key words: atherosclerosis, cellular immunity, cytokines, growth factors, intimal hyperplasia, mast cells, restenosis, vasculopathies.

L'athérosclérose et la resténose font suite à une lésion vasculaire suivie d'une réponse inflammatoire et fibroproliférative qui met en cause un grand nombre de facteurs de croissance, de cytokines et de composantes cellulaires. L'activation des plaquettes et le recrutement des leucocytes dans l'intima artériel jouent rôle crucial, en déclenchant la vaste gamme de réactions conduisant à l'hyperplasie des cellules musculaire artérielles et à la migration intimale. On discute des rôles des macrophages, des lymphocytes et des mastocytes comme médiateurs d'inflammation et de réponse immunitaire, ainsi que des rôles des facteurs de croissance et des cytokines. Un nouvel éclairage sur les « vieux » problèmes nous aidera à trouver des stratégies thérapeutiques novatrices et plus efficaces pour combattre ces entités cliniques.Mots clés : athérosclérose, immunité cellulaire, cytokines, facteurs de croissance, hyperplasie intimale, mastocytes, resténoses, vasculopathies.[Traduit par la Rédaction]

Document Type: Research Article

Publication date: August 1, 2005

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