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The control of vascular smooth muscle function: My life-long learning and continuous discovery with Professor E.E. Daniel

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This communication is neither a comprehensive review of my research, nor a description about my recent new original scientific findings in smooth muscle or in cell Ca2+. For that intention, I will choose to publish via a regular channel, certainly not in this special edition. My intention is to take this opportunity to recapitulate Dr. Daniel's thoughts and spirits through the progress of my research, teaching, and personal development at McMaster University, stemming largely from Dr. Daniel's life-long interest in the regulation of Ca2+ in the control of smooth muscle function, specifically the vascular smooth muscle. Being a culturally adsorbent person, I am sure that my thoughts and behavior must have been substantially influenced by Dr. Daniel over 27 years of our collaboration. His influence may have molded me into whom and what I am today, both socially and scientifically. Equally, I may also have influenced him in some particular or peculiar way. Dr. Daniel's academic contribution is globally well known for, but not limited to, his insightful and productive research in smooth muscle, but also for his effective application of problem-based learning to education in pharmacology and his influence on students and colleagues.Key words: vascular biology, smooth muscle, endothelial cell, calcium regulation, herbal pharmacology, hypertension, problem-based learning.

La présente communication ne constitue ni un examen complet de mes recherches ni une description de mes récentes découvertes scientifiques originales sur les muscles lisses ou le Ca2+ des cellules. Pour ce faire, je choisirais la filière habituelle, mais certainement pas ce numéro spécial. J'ai plutôt l'intention de saisir l'occasion pour revenir sur les pensées et les humeurs du professeur Daniel au fil des progrès de ma recherche, de mon enseignement, et de ma croissance personnelle l'Université McMaster, progrés issus en grande partie de l'intérêt permanent du professeur Daniel pour la régulation du Ca2+ dans la normalisation de la fonction des muscles lisses, en particulier les muscles lisses vasculaires. Compte tenu de ma nature perméable à la culture, je suis sûr que mes pensées et mon comportement ont été considérablement influencés par le professeur Daniel durant nos 27 ans de collaboration. Son influence a peut-étre façonné qui je suis et ce que je suis aujourd'hui sur les plans social et scientifique. De même, je l'ai peut- être moi aussi influencé d'une façon particulière ou spéciale. La contribution du professeur Daniel au milieu universitaire est reconnue mondialement entre autres pour ses recherches lucides et fructueuses sur les muscles lisses, mais aussi pour son application efficace de l'apprentissage par problèmes à l'education en pharmacologie et pour son influence sur ses étudiants et ses collègues.Mots clés : biologie vasculaire, muscle lisse, cellule endothéliale, régulation du calcium, phytopharmacologie, hypertension, apprentissage par problèmes.[Traduit par la Rédaction]

Document Type: Research Article

Publication date: August 1, 2005

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  • Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership.
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