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Thyroid-hormone-induced phosphate absorption in Aplysia californica gut is mediated through protein synthesis

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The mucosal membranes of Aplysia californica forgut epithelia contain a sodium–phosphate symporter that is stimulated by triiodothyronine. Actinomycin D, puromycin, or cycloheximide inhibited the triiodothyronine-stimulated phosphate absorption. It appears that thyroid hormone manifests its effects on phosphate absorption in the A. californica gut through protein synthesis.Key words: phosphate absorption, sodium–phosphate symporter, protein synthesis.

Les membranes muqueuses des épithéliums de l'intestin antérieur de l'Aplysia californica contiennent un symporteur sodium–phosphate qui est stimulé par la triiodothyronine. L'actinomycine D, la puromycine ou le cycloheximide ont inhibé l'absorption de phosphate stimulée par la triiodothyronine. Il semble que l'hormone thyroïdienne exerce ses effets sur l'absorption de phosphate dans l'intestin de l'A. californica par l'intérmédiaire de la synthèse des protéines.Mots clés : absorption de phosphate, symporteur sodium–phosphate, synthèse des protéines.[Traduit par la Rédaction]

Keywords: absorption de phosphate; phosphate absorption; protein synthesis; sodium–phosphate symporter; symporteur sodium–phosphate; synthèse des protéines

Document Type: Research Article

Publication date: December 1, 2002

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