Pressor responsiveness to angiotensin in soy-fed spontaneously hypertensive rats

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Abstract:



Dietary soy may attenuate the development of arterial hypertension. In addition, some soy-containing foods exhibit angiotensin-converting enzyme (ACE) inhibitory properties. Accordingly, we tested the hypothesis that ACE inhibition contributes to the antihypertensive effect of dietary soy. Mean arterial blood pressure (MAP) was recorded from conscious spontaneously hypertensive rats (SHR) at least 24 h after the implantation of catheters. Cumulative dose–response curves to intravenous angiotensin I (AI) (5–100 ng·kg–1·min–1) and angiotensin II (AII) (1–20 ng·kg–1·min–1) were constructed for male, sham-operated female, and ovariectomized female (OVX) SHR that were maintained on either casein or soy diets. The soy diet was associated with a significant reduction in baseline MAP in the OVX SHR (~20 mmHg, 1 mmHg = 133.322 Pa). AI and AII infusions caused graded increases in MAP in all groups. However, there was no significant attenuation of the pressor responses to AI in the soy-fed SHR. Conversely, we observed a significant rightward displacement of the AII dose–response curves in the soy-fed sham-operated and OVX SHR. We conclude that ACE inhibition does not account for the antihypertensive effect of dietary soy in mature SHR.Key words: dietary soy, hypertension, SHR, angiotensin I, angiotensin II.

Le soja alimentaire pourrait atténuer le développement de l'hypertension artérielle. De plus, certains aliments contenant du soja ont des propriété inhibitrices à l'égard de l'enzyme de conversion de l'angiotensine (ECA). Ainsi, nous avons vérifié l'hypothèse que l'inhibition de l'ECA participe à l'effet antihypertenseur du soja alimentaire. La pression artérielle moyenne (PAM) de rats spontanément hypertendus (RSH) éveillés a été enregistrée au moins 24 h après l'implantation de cathéters. Les courbes dose–réponse cumulatives à l'administration intraveineuse d'angiotensine I (AI) (5–100 ng·kg–1·min–1) et d'angiotensine II (AII) (1–20 ng·kg–1·min–1) ont été établies chez des RSH mâles, des RSH femelles ayant subi une opération fictive et des RSH femelles ovariectomisées (OVX) qui ont été soumises à un régime contenant de la caséine ou du soja. Le régime à base de soja a été associé à une réduction significative de la PAM basale chez les RSH OVX (~ 20 mm Hg (1 mm Hg = 133.322 Pa)). Les perfusions de AI et de AII ont provoqué des augmentations graduelles de la PAM chez tous les groupes. Toutefois, il n'y a pas eu d'atténuation significative des réponses pressives à l'AI chez les RSH nourries au soja. Inversement, nous avons observé un déplacement vers la droite significatif des courbes dose–réponse à l'AII chez les RSH OVX et les RSH femelles ayant subi une opération fictive nourries au soja. Nous concluons que l'inhibition de l'ECA n'explique pas l'effet antihypertenseur du soja alimentaire chez les RSH matures.Mots clés : soja alimentaire, hypertension, RSH, angiotensine I, angiotensine II.[Traduit par la Rédaction]

Keywords: RSH; SHR; angiotensin I; angiotensin II; angiotensine I; angiotensine II; dietary soy; hypertension; soja alimentaire

Document Type: Research Article

Publication date: December 1, 2002

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