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Candida krusei: biotechnological potentials and concerns about its safety

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Abstract:

Yeasts have a tradition in biotechnological applications, and Saccharomyces species are the most dominating representatives. Among the yeast species, Candida krusei has been isolated from different habitats, and in recent years, it has gained increased interest because of its diverse biotechnological role. It is found in many fermented food items and dairy products and has also been exploited for production of biochemicals and enzymes. However, because of its opportunistic pathogenic nature, it draws scientific attention regarding the safety of its industrial exploitation. Candida krusei generally causes infections in immunocompromised patients, such as those suffering from Human immunodeficiency virus – acquired immune deficiency syndrome, and also in cancer patients. The recent increase in the use of immunosuppressive drugs has increased the chances of C. krusei infections. Candida krusei possesses an intrinsic resistance to many triazole antifungal drugs, especially fluconazole, which is a main drug used in antifungal therapy; therefore, there is serious concern regarding its safe industrial use.

Keywords: Candida krusei; applications biotechnologiques; biologie de la levure; biotechnological applications; pathogenicity; pathogénicité; yeast biology

Document Type: Research Article

DOI: http://dx.doi.org/10.1139/w2012-077

Affiliations: 1: Institut national de la recherche scientifique – Eau Terre Environnement, Université du Québec, 490, rue de la Couronne, Québec, QC G1K 9A9, Canada. 2: United States Environmental Protection Agency, P.O. Box 17-2141, Kansas City, KS 66117, USA.

Publication date: August 24, 2012

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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