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Curcumin as a promising anticandidal of clinical interest

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Curcumin, an important Asian spice, is part of many Indian food preparations. This work evaluates the antifungal activity of curcumin against 14 strains of Candida (10 clinical and 4 standard). Curcumin displayed antifungal properties against all tested Candida strains, with minimum inhibitory concentrations (MICs) varying from 250 to 2000 µg·mL-1. The in vitro effect of curcumin on growth, sterol content, proteinase secretion, and H+ extrusion by plasma membrane ATPase was investigated for 2 standard strains Candida albicans ATCC 10261 and Candida glabrata ATCC 90030 and compared with the effect of fluconazole. At MIC, curcumin inhibited H+ extrusion in 2 species of Candida by 42% and 32% in the absence of glucose and by 28% and 18% in the presence of glucose. Respective inhibition of H+ extrusion caused by the MIC of fluconazole was 85% and 89% in the absence of glucose and 61% and 66% in its presence. Ergosterol content decreased by 70% and 53% for the 2 strains following exposure to curcumin at MIC; comparative values for fluconazole at MIC were 93% and 98%. Curcumin and fluconazole decreased proteinase secretion by 49% and 53%, respectively, in C. albicans and by 39% and 46%, respectively, in C. glabrata. In conclusion, curcumin is found to be active against all tested clinical and standard strains but is less effective than fluconazole. Antifungal activity of curcumin might be originating from alteration of membrane-associated properties of ATPase activity, ergosterol biosynthesis, and proteinase secretion.

Le curcuma, une épice asiatique importante, entre dans la composition de plusieurs mets indiens. Ce travail vise à évaluer l’activité antifongique du curcuma envers 14 souches de Candida (10 souches cliniques et 4 souches de référence). Le curcuma montrait des propriétés antifongiques envers toutes les souches de Candida testées, les CIM variant de 250 à 2000 µg·mL-1. L’effet du curcuma in vitro sur la croissance, le contenu en stérols, la sécrétion de protéases et l’extrusion du H+ par l’ATPase de la membrane plasmique a été examiné chez 2 souches de référence, Candida albicans ATCC 10261 et Candida glabrata ATCC 90030, et comparé au fluconazole. Le curcuma (CIM) inhibait l’extrusion du H+ chez les 2 espèces de Candida de 42 % et 32 % en absence de glucose, et de 28 % et 18 % en présence de glucose. L’inhibition de l’extrusion de H+ par le fluconazole (CIM) chez les deux souches était de 85 % et 89 % en absence de glucose, et de 61 % et 66 % en sa présence, respectivement. Le contenu en ergostérol diminuait de 70 % et 53 % dans les 2 souches à la suite d’une exposition au curcuma (CIM), les valeurs comparatives du fluconazole (CIM) étant de 93 % et 98 %. Le curcuma et le fluconazole diminuaient la sécrétion de protéases de 49 % et 53 % chez C. albicans, et de 39 % et 46 % chez C. glabrata, respectivement. En conclusion, le curcuma s’avère actif envers toutes les souches cliniques et de référence, mais il est moins efficace que le fluconazole. L’activité antifongique du curcuma peut provenir de la modification de propriétés membranaires associées à l’activité de l’ATPase, à la biosynthèse de l’ergostérol et à la sécrétion des protéases.

Document Type: Research Article

Publication date: March 1, 2011

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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