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The activity of silver against Escherichia coli biofilm is increased by a lipopeptide biosurfactant

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Abstract:

Biological contamination of surfaces, both in industry and in health care, plays an important role as a potential vector of disease transmission. Metals have been described to be effective antibiofilm agents, and the efficacy of silver ions as a disinfectant has been known for centuries. The activity of AgNO3 combined with the lipopeptide biosurfactant V9T14 has been studied against a preformed Escherichia coli biofilm on the Calgary Biofilm Device. Results indicated that the activity of silver can be synergistically enhanced by the presence of V9T14, both allowing for a reduction in the quantity of silver used and for greater antimicrobial activity. The concentration of silver needed to obtain this reduction in the silver-biosurfactant solution was from 129- to 258-fold less than the concentration of silver alone. To our knowledge, this is the first time that a synergistic interaction between a lipopeptide biosurfactant and silver has been observed.

La contamination biologique de surfaces en milieu industriel ou hospitalier constitue un vecteur potentiel important de transmission de maladies. Les métaux ont été décrits comme agents anti-biofilms efficaces, et l’efficacité désinfectante des ions argent est connue depuis des siècles. L’activité du AgNo3 combiné au V9T14, un lipopeptide surfactant biologique, a été étudiée sur un biofilm d’Escherichia coli préformé sur le dispositif à biofilm de Calgary. Les résultats ont indiqué que l’activité de l’argent peut être augmentée de façon synergique par la présence de V9T14, réduisant de la quantité d’argent utilisée et ce, pour une plus grande activité antimicrobienne. La concentration d’argent nécessaire à l’obtention de cet effet dans la solution de surfactant biologique était 129 à 258 fois moins élevée que lorsque l’argent était utilisé seul. À notre connaissance, c’est la première fois qu’une interaction synergique entre un lipopeptide surfactant biologique et l’argent est observée.

Document Type: Research Article

Publication date: March 1, 2010

More about this publication?
  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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