A dual mode of regulation of flgM by ScoC in Bacillus subtilis

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Abstract:

In Bacillus subtilis, the transition state regulator ScoC indirectly, negatively regulates the anti-D factor FlgM in a SinR-dependent pathway leading to an increased availability of D. In addition to the SinR-dependent pathway, ScoC negatively regulates FlgM via directly repressing flgM transcription by binding to two sites in the promoter region of the flgM operon. Our studies also show that the regulation of FlgM by SinR is not at the transcriptional or translational levels. Thus, ScoC shows a dual mode of downregulation of FlgM, via both SinR-dependent and -independent pathways, which eventually results in the increased D activity.

Chez Bacillus subtilis, le régulateur de l’état de transition ScoC régule négativement et indirectement le facteur anti-D, FlgM, suivant une voie dépendante de SinR, conduisant en une augmentation de la disponibilité de D. En plus de la voie dépendante de SinR, ScoC régule négativement FlgM en réprimant directement la transcription de flgM en se liant sur deux sites de la région du promoteur de l’opéron flgM. Nos études montrent aussi que la régulation de FlgM par SinR ne survient pas au niveau de la transcription ni de la traduction. Ainsi, ScoC présente un double mode de régulation négative de FlgM, via des voies dépendantes et indépendantes de SinR, ce qui, éventuellement, résulte en une augmentation de l’activité de D.

Document Type: Research Article

Publication date: August 1, 2009

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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