If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Innate immunity prevents tissue invasion by Entamoeba histolytica

$50.00 plus tax (Refund Policy)

Buy Article:


Although innate and adaptive immunity both play a role in amoebiasis, the mechanisms involved in the elimination of Entamoeba histolytica are poorly understood. To provide more information about the innate immune mechanisms that may confer protection against invasive amoebiasis, we administered inflammatory substances (bacillus Calmette-Guérin, lipopolysaccharide, complete Freund’s adjuvant, or mineral oil) into the peritoneum of hamsters. The animals were then challenged with pathogenic trophozoites of E. histolytica and, after 7 days, the protective host response was analysed. We found that the nonspecific inflammatory response induced in the peritoneum was sufficient to prevent liver invasion by E. histolytica. In vitro experiments showed that the killing of trophozoites was mediated by peritoneal macrophages and a protein of 68 kDa with peroxidase activity.

Même si l’immunité innée et acquise jouent toutes deux un rôle lors de l’amoebiase, les mécanismes impliqués dans l’élimination d’Entameoba histolytica sont mal compris. Afin d’obtenir plus d’informations sur les mécanismes de l’immunité innée qui pourraient conférer une protection contre l’amoebiase invasive, nous avons administré des agents inflammatoires (bacillus Calmette-Guérin, lipopolysaccharide, adjuvant complet de Freund ou de l’huile minérale) dans le péritoine du hamster. Les animaux ont été soumis à une provocation avec les trophozoïtes pathogènes d’E. histolytica et la protection de l’hôte a été analysée après 7 jours. Nous avons trouvé que la réponse inflammatoire non-spécifique induite dans le péritoine était suffisante pour prévenir l’invasion hépatique par E. histolytica. Des expériences in vitro ont démontré que la destruction des trophozoïtes était réalisée par l’intermédiaire des macrophages péritonéaux et d’une protéine de 68 kDa possédant une activité peroxydase.

Document Type: Research Article

Publication date: December 1, 2008

More about this publication?
  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Terms & Conditions
  • Sample Issue
  • Reprints & Permissions
  • ingentaconnect is not responsible for the content or availability of external websites



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more