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Heat stability of chaetoglobosins A and C

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Chaetomium globosum is commonly found in water-damaged buildings and produces the mycotoxins chaetoglobosin A and chaetoglobosin C (Ch-A and Ch-C, respectively). While attempting to purify Ch-A and Ch-C, we observed that these mycotoxins were broken down after heating. The objective of this study was to determine the temperature and the amount of time necessary to break down Ch-A and Ch-C. We demonstrated that the amounts of Ch-A were significantly reduced when exposed to 75 °C for 24 h and 100 °C for 90, 120, or 150 min. Under the same conditions, the levels of Ch-C were also lower (although not significantly). At 175 °C, no Ch-A was detected after 15 min and Ch-C was significantly reduced after 30 min. Our findings will aid other researchers who work with these mycotoxins in the future.

Chaetomium globosum est fréquemment trouvé dans les édifices endommagés par l’eau et produit deux mycotoxines appelées chaetoglobosine A et chaetoglobosine C (Ch-A et Ch-C, respectivement). Lors de tentatives de purification de Ch-A et Ch-C, nous avons observé que ces mycotoxines étaient brisées après le chauffage. L’objectif de cette étude était de déterminer la température et le temps requis pour briser Ch-A et Ch-C. Nous avons démontré que les quantités de la Ch-A étaient significativement réduites après une exposition à 75 °C pendant 24 h ou à 100 °C pendant 90, 120 ou 150 min. Sous les mêmes conditions, les quantités de la Ch-C étaient aussi plus faibles (quoique non significatif). À 175 °C, la Ch-A n’était pas détectable après 15 min et les quantités de Ch-C étaient significativement réduites après 30 min. Nos résultats pourront aider à l’avenir d’autres chercheurs qui travaillent sur ces mycotoxines.

Document Type: Research Article

Publication date: 2008-05-01

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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