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Immune complexes in early Lyme disease

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The study investigated the presence of Borrelia-specific antibodies captured in immune complexes (ICs) in patients with early Lyme disease manifested by erythema migrans. Out of 18 patients, 15 (83.3%) tested positive for polyethylene glycol-precipitated ICs containing IgM antibodies, while only 4 (22.2%) were IgG positive. These results are in accordance with our findings obtained by standard ELISA and recombinant blot, which indicated that ICs might be used for serological diagnosis of the early disease.

Nous avons investigué la présence d’anticorps spécifiques à Borrelia capturés dans les complexes immuns (CI) de patients souffrant de la maladie de Lyme au stade précoce, caractérisée par un erythema migrans. Des 18 patients, 15 (83,3%) étaient positifs lors de tests de précipitation par le polyéthylène glycol des CI contenant des anticorps IgM, alors que 4 seulement (22,2%) étaient positifs quant à la présence d’IgG. Ces résultats concordent avec les résultats que nous avons obtenus par ELISA standard et par buvardage de recombinants qui indiquaient que les CI pouvaient être utilisés dans le diagnostic sérologique du stade précoce de la maladie.

Document Type: Research Article

Publication date: December 1, 2007

More about this publication?
  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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