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Modulation of Congo-red-induced aberrations in the yeast Saccharomyces cerevisiae by the general stress response protein Hsp12p

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Previous studies have shown that in Saccharomyces cerevisiae HSP12, which codes for the small cell wall heat shock protein Hsp12p, was induced upon exposure to cell-wall-damaging agents such as Congo red. Here, we demonstrate that Hsp12p decreases the interaction between Congo red and chitin. A Δhsp12 mutant strain displayed decreased viability, increased aggregation and sedimentation, as well as an altered morphology when grown in the presence of Congo red dye. The presence of Hsp12p was also necessary for the Congo-red-mediated invasion of agar plates.

Des études précédentes ont démontré que le gène HSP12 qui code la petite protéine de choc thermique Hsp12p de la paroi cellulaire Saccharomyces cerevisiae était induit par une exposition à des agents qui endommagent la paroi cellulaire comme le rouge Congo. Ce manuscrit montre que la Hsp12p diminue l’interaction entre le rouge Congo et la chitine. Chez une souche mutante Δhsp12, la viabilité était réduite, l’agrégation et la sédimentation étaient augmentées et la morphologie était altérée lorsque les cellules étaient cultivées en présence de ce colorant. La présence de Hsp12p était aussi nécessaire à l’invasion de gélose dépendante du rouge Congo.

Document Type: Research Article

Publication date: November 1, 2007

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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